Pair Name	Resveratrol, Olaparib
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->DNA damage
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL-xL	hsa598
	Down-regulation	Expression	BRCA1	hsa672
	Down-regulation	Expression	PARP1	hsa142
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
	T-47D	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0553
In Vivo Model	Tumor was induced by injecting MCF-7 cells (1 × 107 in 200 μL sterile 1X PBS) on the right breast fat pads of 6–7 weeks old female BALB/c mice. After formation of tumor, the mice were orally treated with RES + OLA combination (40 mg/kg RES and 20 nM/kg OLA per day) for 30 days.
Result	RES + OLA combination treatment enhanced breast cancer cell death by causing excessive DNA damage and also simultaneously inhibiting the HR pathway.